The story is about a team of trained secret agent guinea pigs that takes on a mission for the US government. A specially trained squad of guinea pigs is dispatched to stop a diabolical billionaire, who plans to taking over the world with household appliances.

Zohan Dvir works as a Special Agent and lives with his orthodox parents in Israel. He wants to give up this life, which is full of dangerous encounters with Palestinians. While in the process of apprehending a Palestinian activist, known simply as the Phantom, he fakes his death, hides in a dog-kennel on a plane bound for New York, and decides to try his hand as a hair-stylist. He is refused employment initially, but when he offers to work for free, Dahlia hires him as a cleaner. When an hair-stylist, Debbie, quits, Zohan replaces her, wins over elderly female clientèle, and falls in love with Dahlia herself. Before Zohan could propose to her, Dahlia’s landlord, Walbridge, who has been raising rents regularly, hires skinhead goons to terrorize the neighborhood, create misunderstandings between Jews, Muslim, Arabs, and Palestinians, and drive them out, so as to enable him to construct a new building which is topped by a roller coaster. When Zohan decides to confront these skinheads, he does not realize that he is in for quite a few surprises himself.